Cytochrome P-450 CYP11B2

A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.

Also Known As:

CYP11B2; Aldosterone Synthase Cytochrome P-450; Aldosynthase; CYP 11B2; Cytochrome P-450c11AS; Cytochrome P450 11B2; Cytochrome P450Aldo; P450c11AS; 18-hydroxylase, Corticosterone; 18-monooxygenase, Corticosterone; Corticosterone 18 hydroxylase; Corticosterone 18 monooxygenase; Cytochrome P 450 CYP11B2; Cytochrome P 450c11AS; Steroid 18 Hydroxylase; Aldosterone Synthase; Corticosterone 18-hydroxylase; Corticosterone 18-monooxygenase; Steroid 18-Hydroxylase

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Oxidoreductases: 13899
    - Oxygenases: 336
      - Mixed Function Oxygenases: 2207
        Cytochrome P-450 Enzyme System: 5452
        Cytochrome P450 Family 11: 13
        Cytochrome P-450 CYP11B2: 716
        Steroid Hydroxylases: 11
        Cytochrome P-450 CYP11B2: 716
- Cytochromes: 2210
  - Cytochrome P-450 Enzyme System: 5452
    - Cytochrome P450 Family 11: 13
      - Cytochrome P-450 CYP11B2: 716
    - Steroid Hydroxylases: 11
      - Cytochrome P-450 CYP11B2: 716
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Hemeproteins: 196
    - Cytochromes: 2210
      - Cytochrome P-450 Enzyme System: 5452
        Cytochrome P450 Family 11: 13
        Cytochrome P-450 CYP11B2: 716
        Steroid Hydroxylases: 11
        Cytochrome P-450 CYP11B2: 716

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